骨形态发生蛋白（BMPs）：在治疗骨缺损方面的潜在应用
Bone morphogenetic proteins (BMPs): therapeutic potential in healing bony defects.
作者信息
Wang E A
机构信息
Genetics Institute, Cambridge, MA 02140.
出版信息
Trends Biotechnol. 1993 Sep;11(9):379-83. doi: 10.1016/0167-7799(93)90096-R.
The bone morphogenetic proteins (BMPs) belong to a family of proteins that also includes the transforming growth factors beta (TGF-beta) and the inhibins. The BMPs can induce new bone formation in ectopic sites and therefore have enormous potential in bone repair. Studies of fracture-repair models involving BMP-2 suggest that this factor will be useful in healing bony defects in humans. Basic research on the BMPs predict a variety of activities on morphogenesis in systems other than cartilage and bone.
骨形态发生蛋白（BMPs）属于一个蛋白质家族，该家族还包括转化生长因子β（TGF-β）和抑制素。BMPs可在异位部位诱导新骨形成，因此在骨修复方面具有巨大潜力。涉及BMP-2的骨折修复模型研究表明，该因子对人类骨缺损的愈合将有帮助。对BMPs的基础研究预测其在软骨和骨以外的系统中对形态发生有多种作用。
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