Thacharodi D, Rao K P
Biomaterials Division, Central Leather Research Institute, Adyar, Madras, India.
J Chem Technol Biotechnol. 1993;58(2):177-81. doi: 10.1002/jctb.280580211.
Chitosan membranes of 20 microns thickness were prepared by a solvent evaporation technique and crosslinked with different concentrations of glutaraldehyde to obtain membranes of various degrees of crosslinking. These membranes were characterized by thermogravimetric (TG) analysis, differential scanning calorimetry (DSC) and tensile strength studies. The effect of crosslinking on the permeability of membranes to propranolol hydrochloride was evaluated by permeation studies conducted in static glass diffusion cells. A decrease in the thermal stability of chitosan membranes due to crosslinking was observed. The tensile strength of the membranes was improved by crosslinking. The introduction of crosslink points within the membrane reduced its permeability to propranolol hydrochloride as evidenced by decreased permeability and diffusion coefficients. Permeability studies revealed the operation of a pore mechanism in the transport of hydrophilic agents such as propranolol hydrochloride through chitosan and crosslinked chitosan membranes.
通过溶剂蒸发技术制备了厚度为20微米的壳聚糖膜，并用不同浓度的戊二醛进行交联，以获得不同交联度的膜。这些膜通过热重分析（TG）、差示扫描量热法（DSC）和拉伸强度研究进行表征。通过在静态玻璃扩散池中进行的渗透研究，评估了交联对膜对盐酸普萘洛尔渗透性的影响。观察到壳聚糖膜由于交联导致热稳定性降低。交联提高了膜的拉伸强度。膜内交联点的引入降低了其对盐酸普萘洛尔的渗透性，这通过渗透率和扩散系数的降低得到证明。渗透研究揭示了亲水性药物如盐酸普萘洛尔通过壳聚糖和交联壳聚糖膜运输时存在孔机制。
