Thacharodi D, Rao K P
Biomaterials Division, Central Leather Research Institute, Adyar, Madras, India.
Biomaterials. 1995 Jan;16(2):145-8. doi: 10.1016/0142-9612(95)98278-m.
Membrane permeation-controlled transdermal drug delivery systems were prepared using the natural polymer, chitosan. An adhesive sealing technique was used to construct the devices. Propranolol hydrochloride was selected as the model drug for the present study. Chitosan membranes with different permeability to propranolol hydrochloride obtained by controlled cross-linking with glutaraldehyde were used to regulate the drug release in the devices. Chitosan gel was used as the drug reservoir. The ability of these devices to deliver the drug while supported on rabbit pinna skin was tested by conducting in vitro studies in modified Franz diffusion cells. The drug release profiles showed that the drug delivery is completely controlled by the devices. The rate of drug release was found to be dependent on the type of membrane used.
使用天然聚合物壳聚糖制备了膜渗透控制型透皮给药系统。采用粘合剂密封技术构建这些装置。选择盐酸普萘洛尔作为本研究的模型药物。通过与戊二醛进行可控交联获得的对盐酸普萘洛尔具有不同渗透性的壳聚糖膜，用于调节装置中的药物释放。壳聚糖凝胶用作药物储库。通过在改良的Franz扩散池中进行体外研究，测试了这些装置在兔耳廓皮肤上支撑时递送药物的能力。药物释放曲线表明，药物递送完全由这些装置控制。发现药物释放速率取决于所用膜的类型。
