Mahato S B, Majumdar I
Indian Institute of Chemical Biology, Jadavpur, Calcutta.
Phytochemistry. 1993 Nov;34(4):883-98. doi: 10.1016/s0031-9422(00)90685-x.
Microbial transformations of various steroids are reviewed. Developmental studies on immobilization of microbial cells, techniques for selective transformation and better yields of desired metabolites are highlighted. The present position of microbial biotechnology in the steroid drug industry and the future prospects are discussed. Various steroid substrates, their metabolites and the micro-organisms used for the transformations are compiled covering the literature for the period late 1987-mid 1992.
本文综述了各种甾体的微生物转化。重点介绍了微生物细胞固定化的发展研究、选择性转化技术以及所需代谢物的更高产量。讨论了微生物生物技术在甾体药物工业中的现状和未来前景。汇编了1987年末至1992年年中期间文献中涉及的各种甾体底物、它们的代谢物以及用于转化的微生物。
