一种神经肽，烟草天蛾FLRF酰胺，对天蛾科蛾类甘薯天蛾中肠活性的抑制作用。

The inhibitory effect of a neuropeptide, ManducaFLRFamide, on the midgut activity of the sphingid moth, Agrius convolvuli.

作者信息

Fujisawa Y, Shimoda M, Kiguchi K, Ichikawa T, Fujita N

机构信息

International Research Laboratories, Ciba-Geigy Japan Ltd., Takarazuka.

出版信息

Zoolog Sci. 1993 Oct;10(5):773-7.

PMID:7764371

Abstract

The effect of ManducaFLRFamide, a neuropeptide originally isolated from the central nervous system of a sphingid moth, Manduca sexta, was examined on the midgut motility of another sphingid moth, Agrius convolvuli. The peptide was shown to suppress the spontaneous contractions of the isolated gut in adult Agrius at low concentrations (> or = 10(-10) M). Immunoreactivity against anti-FMRFamide antiserum was also detected in the brain-suboesophageal ganglion and the retrocerebral neurohaemal organs of the moth. These observations suggest that ManducaFLRFamide, or its closely-related analog, is a neuropeptide which regulates the activity of the digestive tract in Agrius.

摘要

最初从烟草天蛾（Manduca sexta）中枢神经系统中分离出的一种神经肽——烟草天蛾FLRF酰胺（ManducaFLRFamide），对另一种天蛾——甘薯天蛾（Agrius convolvuli）中肠运动的影响进行了研究。结果表明，该肽在低浓度（≥10^(-10) M）时可抑制成年甘薯天蛾离体肠道的自发收缩。在该蛾的脑 - 咽下神经节和脑后神经血器官中也检测到了针对抗FMRF酰胺抗血清的免疫反应性。这些观察结果表明，烟草天蛾FLRF酰胺或其密切相关的类似物是一种调节甘薯天蛾消化道活性的神经肽。