Grausz J D
Fondation Jean Dausset (CEPH), Human Polymorphism Study Center, Paris, France.
Curr Opin Biotechnol. 1993 Dec;4(6):665-71. doi: 10.1016/0958-1669(93)90047-z.
Over the past four years, the CEPH (Jean Dausset Foundation) has expanded its linkage mapping effort to include physical mapping and, in 1990, co-founded the Genethon to ensure that a combined physical and genetic map of the entire human genome would be achieved. The Genethon has applied methods developed at CEPH on an industrial scale to accomplish the colossal task of constructing an integrated map. It is the role of such an integrated map to accelerate the search for the genes responsible for inherited diseases, and the results of the past 12 months encourage our optimism that this goal will be realized rapidly. These discoveries are providing not only an approach to the diagnosis of genetically based disease but also some of the first breakthroughs in the area of gene therapy.
在过去四年中，CEPH（让·多塞基金会）扩大了其连锁图谱绘制工作，将物理图谱绘制纳入其中，并于1990年共同创立了吉内通公司，以确保实现整个人类基因组的物理图谱与遗传图谱的结合。吉内通公司将CEPH开发的方法应用于工业规模，以完成构建综合图谱这一艰巨任务。这样一个综合图谱的作用是加速寻找导致遗传性疾病的基因，过去12个月的成果让我们乐观地认为这一目标将很快实现。这些发现不仅为基于基因的疾病诊断提供了一种方法，也在基因治疗领域取得了一些初步突破。
