1993 - 1994年热那亚人类遗传连锁图谱。
The 1993-94 Généthon human genetic linkage map.
作者信息
Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J
机构信息
Centre d'Etudes du Polymorphisme Humain, Paris, France.
出版信息
Nat Genet. 1994 Jun;7(2 Spec No):246-339. doi: 10.1038/ng0694supp-246.
In 1992, we described a second-generation genetic linkage map of the human genome. Using 1,267 new microsatellite markers, we now present a new genetic linkage map containing a total of 2,066 (AC)n short tandem repeats, 60% of which show a heterozygosity of over 0.7. Statistical linkage analysis based on the genotyping of eight large CEPH families placed these markers in the 23 linkage groups. The map includes 1,266 intervals and spans a total distance of 3690 centiMorgans (cM). A total of 1,041 markers could be ordered with odds ratios greater than 1000:1. About 56% of this map is at a distance of 1 cM or less from one of its markers.
1992年，我们描述了人类基因组的第二代遗传连锁图谱。利用1267个新的微卫星标记，我们现在展示了一张新的遗传连锁图谱，其中总共包含2066个(AC)n短串联重复序列，其中60%的杂合度超过0.7。基于对八个大型CEPH家系的基因分型进行的统计连锁分析将这些标记置于23个连锁群中。该图谱包括1266个区间，总跨度为3690厘摩(cM)。总共1041个标记可以以大于1000:1的优势比进行排序。该图谱约56%的区域距离其标记之一在1 cM或更小的距离内。
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