Scott J K, Craig L
Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada.
Curr Opin Biotechnol. 1994 Feb;5(1):40-8. doi: 10.1016/s0958-1669(05)80068-0.
Over the past year, great strides have been made in the design of peptide libraries, and new approaches have been developed for identifying peptide ligands. The libraries comprise large collections of peptides, ranging from 1 million to 1 billion different sequences, which can be screened using monoclonal and polyclonal antibodies, receptors, enzymes or other target molecules. The power of this technology stems from the chemical diversity of the amino acids coupled with the large number of sequences in a library. As such, peptide libraries may be useful for finding ligands that can serve as leads for pharmaceutical development and other purposes.
在过去的一年里，肽库设计取得了巨大进展，并且已经开发出用于鉴定肽配体的新方法。这些文库包含大量的肽，序列数量从100万到10亿不等，可使用单克隆抗体、多克隆抗体、受体、酶或其他靶分子进行筛选。这项技术的强大之处源于氨基酸的化学多样性以及文库中大量的序列。因此，肽库可能有助于找到可作为药物开发及其他用途先导物的配体。
