噬菌体展示肽库
Phage-displayed peptide libraries.
作者信息
Zwick M B, Shen J, Scott J K
机构信息
Biochemistry Program, Simon Fraser University, Burnaby, BC, Canada.
出版信息
Curr Opin Biotechnol. 1998 Aug;9(4):427-36. doi: 10.1016/s0958-1669(98)80017-7.
Abstract
Over the past year, significant advances have been achieved through the use of phage-displayed peptide libraries. A wide variety of bioactive molecules, including antibodies, receptors and enzymes, have selected high-affinity and/or highly-specific peptide ligands from a number of different types of peptide library. The demonstrated therapeutic potential of some of these peptides, as well as new insights into protein structure and function that peptide ligands have provided, highlight the progress made within this rapidly-expanding field.
摘要
在过去的一年里，通过使用噬菌体展示肽库取得了重大进展。包括抗体、受体和酶在内的各种各样的生物活性分子，已从多种不同类型的肽库中筛选出高亲和力和/或高特异性的肽配体。其中一些肽已展现出治疗潜力，肽配体所提供的关于蛋白质结构和功能的新见解，凸显了在这个快速发展的领域所取得的进展。
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