Tomosaka H, Omata S, Anzai K
Department of Biosystem Science, Graduate School of Science and Technology, Niigata University, Japan.
Biosci Biotechnol Biochem. 1994 Aug;58(8):1420-3. doi: 10.1271/bbb.58.1420.
Mutagenic activity and DNA intercalation were examined for 9-aminoacridine (9-AA) and its derivatives. Introduction of a nitro group into the 9-AA molecule was found to enhance the activity enormously as was detected by the Ames test. Acetylation of amino group at 9-position of acridine ring inhibited the intercalation, the frameshift activity disappearing. Rat liver S9 converted 9-AA metabolically to 9-amino-2-hydroxyacridine.
