Tomosaka H, Omata S, Hasegawa E, Anzai K
Department of Biosystem Science, Graduate School of Science and Technology, Niigata University, Japan.
Biosci Biotechnol Biochem. 1997 Jul;61(7):1121-5. doi: 10.1271/bbb.61.1121.
Some derivatives of 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding affinity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding affinity, while the introduction of chlorine increased them. Halogenated derivatives of 1 showed higher toxicity against Salmonella typhimurium TA1537.
合成了9-氨基吖啶（1）的一些衍生物，并研究了它们的移码诱变活性和与DNA的结合亲和力。在1的吖啶环中引入甲基会降低诱变活性和嵌入性DNA结合亲和力，而引入氯则会增加这些性质。1的卤代衍生物对鼠伤寒沙门氏菌TA1537显示出更高的毒性。
