Trapnell B C, Gorziglia M
Genetic Therapy Inc, Gaithersburg.
Curr Opin Biotechnol. 1994 Dec;5(6):617-25. doi: 10.1016/0958-1669(94)90084-1.
Growing interest in adenoviral gene-transfer vectors, stimulated by efforts to develop in vivo gene therapy for cystic fibrosis, has led to an evaluation of their use in many other applications of in vivo gene therapy. Studies are beginning to define strategies for the efficient, albeit transient, expression of the transferred gene and have further identified and partially characterized important host responses to in vivo gene transfer that modulate the duration of expression of the transgene. Ongoing work is actively exploring these issues, with a view to the design of the next generation of adenoviral vectors.
对腺病毒基因转移载体兴趣的不断增加，受到开发囊性纤维化体内基因疗法努力的刺激，已导致对其在许多其他体内基因疗法应用中的使用进行评估。研究开始确定有效（尽管是短暂的）表达转移基因的策略，并进一步识别和部分表征了对体内基因转移的重要宿主反应，这些反应调节转基因的表达持续时间。正在进行的工作正在积极探索这些问题，以期设计下一代腺病毒载体。
