Zacest R, Frewin D B, Robinson M A, Wilson L L, Lawrence J R, Clarkson A R, Jackson B
Drugs. 1976;11 SUPPL 1:177-84. doi: 10.2165/00003495-197600111-00036.
Thirteen patients whose hypertension had been resistant to conventional drug therapy, had minoxidil added to their regimen in doses from 5 to 60 mg/day. All responded with satisfactory reductions of blood pressure to mean values of 149/90mm Hg (supine) and 143/89mm Hg (standing). A significant portion of their previous antihypertensive therapy was either greatly decreased or withdrawn completely. Although fluid retention occurred in most patients as the dose of minoxidil was increased, this could be successfully checked by the use of diuretics. It was considered that in addition to beta-adrenoreceptor blocking drugs to control the reflexly induced cardiac stimulation, sufficiently aggressive diuretic therapy is mandatory to ensure the successful use of this drug. Haemodynamic evaluations in seven patients clearly showed that lowering of blood pressure was the result of decreases in peripheral vascular resistance as significant increases in the cardiac index occurred in all patients.
13名高血压患者对传统药物治疗耐药，在其治疗方案中添加了米诺地尔，剂量为每日5至60毫克。所有人的血压均有满意下降，仰卧位平均血压降至149/90毫米汞柱，站立位降至143/89毫米汞柱。他们之前的大部分抗高血压治疗要么大幅减少，要么完全停用。尽管随着米诺地尔剂量增加，大多数患者出现了液体潴留，但使用利尿剂可成功控制。人们认为，除了使用β-肾上腺素能受体阻滞剂来控制反射性引起的心脏刺激外，必须进行足够积极的利尿治疗，以确保该药物的成功使用。对7名患者的血流动力学评估清楚地表明，血压降低是外周血管阻力降低的结果，因为所有患者的心脏指数均显著增加。
