Motta M, Daniels E L, Martini L
Endocrinol Exp. 1975 Jan;9(1):3-9.
Electrolytic lesions placed in the median eminence of adult male rats are followed, in 7--10 days, by a significant decrease in pituitary FSH concentration. The intravenous injection of a hypothalamic extract prepared from normal animals induces, in 45 minutes, a significant increase in the amounts of FSH stored in the pituitary of median eminence-lesioned animals. The concentration of FSH in the pituitary of lesioned animals is also increased to normal by the intravenous injection of an extract prepared from the isolated hypothalamic island of animals previously submitted to a total "hypothalamic deafferentation", in spite of the fact that this does not contain any FSH-RF activity. It is suggested that the hypothalamus possesses separate humoral factors for the regulation of the release and of the synthesis of pituitary FSH.
对成年雄性大鼠正中隆起进行电解损伤后，7至10天内，垂体促卵泡素（FSH）浓度显著降低。静脉注射由正常动物制备的下丘脑提取物，45分钟内，正中隆起损伤动物垂体中储存的FSH量显著增加。尽管从先前接受“下丘脑完全去传入神经支配”的动物分离出的下丘脑岛制备的提取物不含任何促卵泡素释放因子（FSH-RF）活性，但静脉注射该提取物也可使损伤动物垂体中的FSH浓度恢复正常。这表明下丘脑具有调节垂体FSH释放和合成的独立体液因子。
