Kitahara T, Aono S, Mori K
Department of Applied Biological Chemistry, University of Tokyo, Japan.
Biosci Biotechnol Biochem. 1995 Jan;59(1):78-82. doi: 10.1271/bbb.59.78.
Both the enantiomers of aseanostatin P5 (sarcinic acid), an inhibitor of myeloperoxidase (MPO) release from human polymorphonuclear leukocytes (PMN), with high optical purity were synthesized by starting from (S)-2-methylbutanol and methyl (S)-3-hydroxy-2-methylpropanoate. They were converted to four diastereomers of aggreceride A, a platelet aggregation inhibitor.
髓过氧化物酶（MPO）从人多形核白细胞（PMN）释放的抑制剂——东南亚他汀P5（肌氨酸）的两种对映体，以（S）-2-甲基丁醇和（S）-3-羟基-2-甲基丙酸甲酯为起始原料合成，具有高光学纯度。它们被转化为血小板聚集抑制剂——聚集脂A的四种非对映异构体。
