Morris R G, Rushe T, Woodruffe P W, Murray R M
Department of Psychology, Institute of Psychiatry, De Crespigny Park, London, UK.
Schizophr Res. 1995 Feb;14(3):235-46. doi: 10.1016/0920-9964(94)00044-9.
The study investigated problem solving ability in schizophrenia. Thirty DSM-IIIR schizophrenic patients and 27 matched normal controls were tested on the Three-Dimensional Computerised Tower of London Test (3-D CTL Test) (Morris et al., 1993). The patients took significantly more moves to solve a series of problems and solved significantly fewer problems in the predetermined minimum number of moves. The patients response times, as measured using a control version of the task (the 3-D CTL Control), were longer than those of the controls. However, when latencies were adjusted to take into account the slower responses overall, the patients planning times were not significantly increased. Inaccurate planning, as defined by taking more moves, did not correlate with either positive or negative symptoms, but the response times tended to be longer in patients who had more negative symptoms. The findings suggest that there is a deficit in problem solving activity in schizophrenia that may be associated with translating 'willed intentions' into action, independent of slower motor speed.
该研究调查了精神分裂症患者的问题解决能力。对30名符合《精神疾病诊断与统计手册》第三版修订本(DSM-IIIR)的精神分裂症患者和27名匹配的正常对照者进行了三维计算机化伦敦塔测试(3-D CTL测试)(莫里斯等人,1993年)。患者解决一系列问题时移动次数显著更多,且在预定的最少移动次数内解决的问题显著更少。使用该任务的对照版本(3-D CTL对照)测量时,患者的反应时间比对照组更长。然而,当对潜伏期进行调整以考虑到总体反应较慢的情况时,患者的计划时间并未显著增加。以移动次数更多来定义的不准确计划,与阳性或阴性症状均无关联,但阴性症状较多的患者反应时间往往更长。研究结果表明,精神分裂症患者在问题解决活动方面存在缺陷,这可能与将“意愿意图”转化为行动有关,与运动速度较慢无关。