Kato S, Karino K, Hasegawa S, Nagasawa J, Nagasaki A, Eguchi M, Ichinose T, Tago K, Okumori H, Hamatani K
Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University of Agriculture, Japan.
Br J Nutr. 1995 Mar;73(3):433-41. doi: 10.1079/bjn19950045.
The effect of dietary octacosanol, a long-chain alcohol, on lipid metabolism was investigated in rats fed on a high-fat diet for 20 d. The addition of octacosanol (10 g/kg diet) to the high-fat diet led to a significant reduction (P < 0.05) in the perirenal adipose tissue weight without decrease of the cell number, suggesting that octacosanol may suppress lipid accumulation in this tissue, whereas no effect was seen in the epididymal adipose tissue weight and in the lipid content in liver. Octacosanol supplementation decreased the serum triacylglycerol concentration, and enhanced the concentration of serum fatty acids, probably through inhibition of hepatic phosphatidate phosphohydrolase (EC 3.1.3.4). Though the activity of hormone-sensitive lipase (EC 3.1.1.3) was not influenced by octacosanol, higher activities of lipoprotein lipase (EC 3.1.1.34) in the perirenal adipose tissue and the total oxidation rate of fatty acid in muscle were observed. Lipid absorption was not affected by the inclusion of octacosanol. Thus, the present results suggest that the dietary incorporation of octacosanol into a high-fat diet affects some aspects of lipid metabolism.
研究了在高脂饮食喂养20天的大鼠中，膳食二十八烷醇（一种长链醇）对脂质代谢的影响。在高脂饮食中添加二十八烷醇（10克/千克饮食）导致肾周脂肪组织重量显著降低（P < 0.05），而细胞数量未减少，这表明二十八烷醇可能抑制该组织中的脂质积累，而附睾脂肪组织重量和肝脏脂质含量未见影响。补充二十八烷醇可降低血清三酰甘油浓度，并提高血清脂肪酸浓度，这可能是通过抑制肝磷脂酸磷酸水解酶（EC 3.1.3.4）实现的。虽然激素敏感性脂肪酶（EC 3.1.1.3）的活性不受二十八烷醇影响，但观察到肾周脂肪组织中脂蛋白脂肪酶（EC 3.1.1.34）的活性较高，且肌肉中脂肪酸的总氧化率较高。二十八烷醇的添加对脂质吸收没有影响。因此，目前的结果表明，在高脂饮食中添加二十八烷醇会影响脂质代谢的某些方面。
