Romanova E V, Gaevyĭ M D
Farmakol Toksikol. 1976 Mar-Apr;39(2):173-6.
The effect of thiamine-bromide (5-7 mg/kg, intravenously) on the cerebral blood flow circulation rate; total arterial pressure, oxygen tension in the brain tissues (measured polarographically) and pressure in the venous vessels of the brain was investigated on anesthetized cats with controlled respiration. In patients with hypertensive disease (essential hypertension) the action of the agent (1 ml of a 6% solution, intramuscularly) on the rheoencephalographic readings and overall arterial pressure was studied. Thiamine-bromide is shown to lower the tonicity of intra- and extracranial vessels and to increase pulsed variations in the volume of blood filling of the cranial vessels. The hypotensive effect of the drug is pronounced but mildly. The oxygen tension in cerebral vessels depended mainly on changes in the cerebral circulation rate.
研究了溴化硫胺（5 - 7毫克/千克，静脉注射）对呼吸受控的麻醉猫脑血流循环速率、总动脉压、脑组织氧张力（用极谱法测量）和脑静脉血管压力的影响。对高血压病（原发性高血压）患者，研究了该药物（1毫升6%溶液，肌肉注射）对脑电阻图读数和总动脉压的作用。结果表明，溴化硫胺可降低颅内和颅外血管的张力，并增加颅血管充血量的脉冲变化。该药物的降压作用明显但较弱。脑血管中的氧张力主要取决于脑循环速率的变化。
