Gaevyĭ M D, Romanova E V
Farmakol Toksikol. 1975 Sep-Oct;38(5):572-6.
The effect of sodium salicylate (100 mg/kg intravenously) on the circulation rate of the cerebral blood flow, total arterial pressure, oxygen tension in the cerebral tissue (by the polarographic method) and on the pressure in the brain venous vessels was studied on anesthetized cats with controlled respiration. In rheumatic patients the action of the drug (10 ml of a 10% solution, intravenously) on the rheoencephalographic findings and the total arterial pressure was investigated. Sodium salicylate was shown to raise the tonicity of the intra- and extracranial vessels, to lower the amplitude of the pulse fluctuations and to highten the total arterial pressure. The cerebral circulation depends upon changes in the tonicity of the cerebral vessels and on the total arterial pressure, i. e. with a significant rise of the latter it increases in spite of a greater vascular resistance. Changes in the blood flow are followed by corresponding variations in the PO2 of the brain tissue. No significant changes of the pressure in the venous system of the brain could be established.
在控制呼吸的麻醉猫身上，研究了水杨酸钠（静脉注射100毫克/千克）对脑血流循环速率、总动脉压、脑组织中的氧张力（采用极谱法）以及脑静脉血管压力的影响。在风湿性患者中，研究了该药物（10%溶液10毫升，静脉注射）对脑电阻图结果和总动脉压的作用。结果表明，水杨酸钠可提高颅内和颅外血管的张力，降低脉搏波动幅度，并升高总动脉压。脑循环取决于脑血管张力的变化和总动脉压，即尽管血管阻力增大，但总动脉压显著升高时，脑循环仍会增加。血流变化后，脑组织的PO2会发生相应变化。未发现脑静脉系统压力有明显变化。
