Golub M S, Donald J M
California Regional Primate Research Center, University of California, Davis 95616-8542, USA.
Biol Neonate. 1995;67(2):140-8. doi: 10.1159/000244155.
Potential long-term effects of intrapartum meperidine were studied in rhesus monkey infants whose dams received 0, 2, or 3 mg/kg meperidine, i.v., during labor (n = 5, 5, 3). Spontaneous behavior and cognitive performance were evaluated at 3-12 months of age. Observation of spontaneous behaviors indicated less age-related increase in quiet activities in drug-exposed infants. In the discrimination reversal test, drug-exposed infants had more balks (p = 0.008) and fewer correct choices (p = 0.008) during initial phases of the first reversal. Due to sex differences in the delayed alternation test, evaluation of drug effects on short-term memory was not possible. In the continuous performance test, drug-exposed infants performed better (NS) and had fewer omission errors (p = 0.034) during the second half of the test period. These initial findings suggest that short-term opiate exposure during labor can alter later behavior of infant monkeys.
对分娩期间静脉注射0、2或3mg/kg哌替啶的恒河猴幼崽（每组n = 5、5、3），研究了分娩期哌替啶可能产生的长期影响。在3至12个月大时评估自发行为和认知能力。对自发行为的观察表明，接触药物的婴儿安静活动随年龄增长的增加较少。在辨别反转试验中，接触药物的婴儿在第一次反转的初始阶段有更多的回避行为（p = 0.008）和更少的正确选择（p = 0.008）。由于延迟交替试验中存在性别差异，因此无法评估药物对短期记忆的影响。在连续操作试验中，接触药物的婴儿在试验期后半段表现更好（无统计学意义），遗漏错误更少（p = 0.034）。这些初步研究结果表明，分娩期间短期接触阿片类药物会改变幼猴的后期行为。
