Golub M S, Eisele J H, Donald J M
California Primate Research Center, University of California, Davies 95616.
Am J Obstet Gynecol. 1988 Nov;159(5):1280-6. doi: 10.1016/0002-9378(88)90464-4.
Infant monkeys (Macaca mulatta) exposed to narcotic analgesics during labor after treatment of dams were evaluated for growth and development over a 14-week period. Ten infants exposed to meperidine (2 mg/kg maternal dose) or alfentanil (0.1 mg/kg maternal dose) were compared with seven controls whose dams received no analgesic. No group differences in weight gain or body growth were observed. Alfentanil-exposed infants appeared to have a higher incidence of infections requiring veterinary treatment. Measures of spontaneous activity showed a significantly higher incidence of immature rest pattern (laying) in the alfentanil group associated with lower overall locomotor activity relative to controls. Meperidine-exposed infants had a generally higher overall level of locomotor activity than controls that was statistically significant at 11 weeks of age. Alfentanil-exposed animals were impaired in performance of a simple cognitive task (object constancy) at 2 to 3 months of age and meperidine-exposed infants showed a similar nonsignificant trend. Gross and fine motor maturations were similar to those of controls. Thus, in this situation, the impact of obstetric analgesic treatment was demonstrable for several months after birth in some limited areas.
在对孕猴进行治疗后，对分娩期间接触麻醉性镇痛药的幼猴（猕猴）进行了为期14周的生长发育评估。将10只接触哌替啶（母体剂量2mg/kg）或阿芬太尼（母体剂量0.1mg/kg）的幼猴与7只母体未接受镇痛药的对照幼猴进行比较。未观察到各组在体重增加或身体生长方面的差异。接触阿芬太尼的幼猴似乎因感染而需要兽医治疗的发生率更高。自发活动测量显示，与对照组相比，阿芬太尼组中出现不成熟休息模式（躺卧）的发生率显著更高，且总体运动活动较低。接触哌替啶的幼猴总体运动活动水平通常高于对照组，在11周龄时具有统计学意义。接触阿芬太尼的动物在2至3个月大时执行简单认知任务（物体恒常性）的能力受损，接触哌替啶的幼猴也表现出类似的无统计学意义的趋势。粗大和精细运动成熟度与对照组相似。因此，在这种情况下，产科镇痛治疗的影响在出生后的几个月内在一些有限的方面是可证明的。
