Cox C, Ma G
Department of Biostatistics, University of Rochester Medical Center, New York 14642, USA.
Biometrics. 1995 Mar;51(1):142-50.
Asymptotic confidence bands for generalized nonlinear regression models are developed. These are based on a combination of the S method of Scheffe, together with the delta method which is used to approximate the mean function by a linear combination of the parameters. The approach can be used in any situation where large sample theory can be applied to yield asymptotically normal estimates of the parameters, together with a consistent estimate of the large sample covariance matrix. Alternative formulations for various special cases allow the use of restricted range bands. A number of examples are given, including a pharmacokinetic model, a logit model with a background response rate, and a parametric survival model.
本文推导了广义非线性回归模型的渐近置信带。这些置信带基于谢费尔(Scheffe)的S方法与德尔塔(delta)方法的结合,其中德尔塔方法用于通过参数的线性组合来近似均值函数。该方法可用于任何能应用大样本理论以得到参数的渐近正态估计以及大样本协方差矩阵的一致估计的情形。针对各种特殊情况的替代公式允许使用受限范围的置信带。文中给出了多个例子,包括一个药代动力学模型、一个具有背景反应率的逻辑回归模型以及一个参数生存模型。