Burt R W, Ratcliffe J G, Stack B H, Cuthbert J, Kennedy R S, Corker C S, Franchimont P, Spilg W G, Stimson W H
Br J Cancer. 1978 May;37(5):714-7. doi: 10.1038/bjc.1978.108.
The prevalence of elevated serum levels of 5 potential tumour-associated antigens was determined in patients with lung cancer sampled at the time of initial presentation, using age- and sex-matched patients with benign lung disease as controls. Elevated levels (greater than upper 95th centile of controls) were found as follows: carcinoembryonic antigen (CEA), 17%; pregnancy-associated alpha-macroglobulin (PAM), 16%; casein 14%; human chorionic gonadotrophin (HCG) 6%; alpha-foetoprotein (AFP), 1.5%. The prevalence of elevated CEA levels (but not other markers) was higher in patients with evidence of extra-thoracic tumour spread (23%) mainly due to anaplastic tumours and adenocarcinomas. A degree of concordance of elevated marker levels occurred with CEA, HCG, casein and AFP, but there was a striking discordance of elevated CEA and PAM levels. Simultaneous assays of CEA and PAM will detect the majority of patients with elevations of any of the markers studied, and are likely to be the most useful biochemical markers in following the response of lung tumours to therapy.
在肺癌患者初次就诊时采集样本，以年龄和性别匹配的良性肺病患者作为对照，测定5种潜在肿瘤相关抗原血清水平升高的患病率。发现水平升高（高于对照的第95百分位数上限）的情况如下：癌胚抗原（CEA），17%；妊娠相关α-巨球蛋白（PAM），16%；酪蛋白，14%；人绒毛膜促性腺激素（HCG），6%；甲胎蛋白（AFP），1.5%。有胸外肿瘤扩散证据的患者（主要是间变性肿瘤和腺癌患者）中CEA水平升高（而非其他标志物）的患病率更高（23%）。CEA、HCG、酪蛋白和AFP的标志物水平升高存在一定程度的一致性，但CEA和PAM水平升高存在明显不一致。同时检测CEA和PAM将检测出大多数所研究标志物中任何一种升高的患者，并且可能是监测肺肿瘤对治疗反应中最有用的生化标志物。
