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Improved synthesis of some commonly used PET radioligands by the use of [11C]methyl triflate.

作者信息

Någren K, Müller L, Halldin C, Swahn C G, Lehikoinen P

机构信息

Turku University Cyclotron/PET Center, Radiopharmaceutical Chemistry Laboratory, Finland.

出版信息

Nucl Med Biol. 1995 Feb;22(2):235-9. doi: 10.1016/0969-8051(94)00083-v.

DOI:10.1016/0969-8051(94)00083-v
PMID:7767319
Abstract

[11C]Methyl triflate was compared with [11C]methyl iodide as a labelled precursor in the synthesis of some commonly used PET radioligands, L-[11C]deprenyl, [11C]m-hydroxyephedrine (MHED), [11C] beta-CIT, [11C] beta-CFT and [11C]SCH 39166 which have been prepared previously in comparatively low yields from [11C]methyl iodide. A new dopamine reuptake radioligand, [11C] alpha-CIT, was also prepared. The results demonstrate that higher yields are obtained with shorter reaction times, lower reaction temperatures and smaller amounts of precursors with [11C]methyl triflate.

摘要

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