Sackmann E, Feder T
Physics Department (Biophysics Group, E22), Technical University of Munich, Garching, Germany.
Mol Membr Biol. 1995 Jan-Mar;12(1):21-8. doi: 10.3109/09687689509038491.
Phase separation in vesicles of lipid mixtures creates an entirely new variety of shapes. The process may be described in terms of a combination of the theory of spinodal decomposition and the membrane bending energy concept. One major aspect discussed is the stabilization of domain structures in intrinsically unstable (phase segregated) states by the coupling between local bending and phase separation. A second topic is the role of interfacial tension for the stability of the domains. We show that vesicle fission is a consequence (1) of the reduction of the interfacial chemical energy or (2) of local phase separation within the neck connecting bud and mother vesicle. Finally, the formation of coated buds in giant vesicles caused by the lateral condensation of membrane-bound macromolecular amphiphiles is described.
脂质混合物囊泡中的相分离产生了全新的各种形状。该过程可以用旋节线分解理论和膜弯曲能概念相结合来描述。讨论的一个主要方面是通过局部弯曲和相分离之间的耦合来稳定本质上不稳定（相分离）状态下的畴结构。第二个主题是界面张力对畴稳定性的作用。我们表明，囊泡裂变是（1）界面化学能降低的结果，或者是（2）连接芽和母囊泡的颈部内局部相分离的结果。最后，描述了由膜结合的大分子两亲物的横向凝聚在巨型囊泡中形成包被芽的过程。
