Marsh D
Max-Planck-Institut für biophysikalische Chemie, Abteilung Spektroskopie, Göttingen, Germany.
Mol Membr Biol. 1995 Jan-Mar;12(1):59-64. doi: 10.3109/09687689509038496.
The specificity of lipid interactions with both integral and peripheral proteins is discussed in terms of the microscopic heterogeneity in lipid distribution to which they give rise. The factors giving rise to macroscopic phase separation, namely hydrophobic mismatch for integral proteins and phase transitions for lipid bilayers, also are considered. Simple thermodynamic or phenomenological models are given for the way in which specific lipid interactions with peripheral or integral proteins may be coupled to intrinsic lipid phase transitions and thus enhance the phase separation or domain formation of the lipid.
从脂质相互作用所导致的脂质分布微观异质性方面，讨论了脂质与整合蛋白和外周蛋白相互作用的特异性。还考虑了导致宏观相分离的因素，即整合蛋白的疏水错配和脂质双层的相变。给出了简单的热力学或唯象模型，用于描述外周或整合蛋白与脂质的特异性相互作用可能与内在脂质相变偶联的方式，从而增强脂质的相分离或结构域形成。
