Zhang Y H, Liu L S
Department of Cardiology, Cardiovascular Institute, Beijing.
Zhonghua Yi Xue Za Zhi. 1995 Feb;75(2):82-4, 125.
Using the isolated working rat heart model, we recorded cardiac function of the hypertrophied hearts induced by abdominal aortic banding and determined the myocardial angiotensin II level. Compared with the sham-operated control hearts, the maximal diastolic rate (-dp/dt) and coronary flow rate (per gram of left ventricular weight) were decreased, while the myocardial angiotensin II content was increased in the hypertrophied hearts. Correlation analysis revealed that both coronary flow rate (r = -0.8097, P < 0.001) and -dp/dt (r = -0.5463, P < 0.01) were negatively correlated to myocardial angiotensin II. We conclude that the activated cardiac renin-angiotensin system may be responsible for the decreased diastolic function and coronary reserve in the hypertrophied hearts.
使用离体工作大鼠心脏模型，我们记录了腹主动脉缩窄诱导的肥厚心脏的心脏功能，并测定了心肌血管紧张素II水平。与假手术对照组心脏相比，肥厚心脏的最大舒张速率（-dp/dt）和冠状动脉血流速率（每克左心室重量）降低，而心肌血管紧张素II含量增加。相关性分析显示，冠状动脉血流速率（r = -0.8097，P < 0.001）和 -dp/dt（r = -0.5463，P < 0.01）均与心肌血管紧张素II呈负相关。我们得出结论，激活的心脏肾素-血管紧张素系统可能是肥厚心脏舒张功能降低和冠状动脉储备减少的原因。
