Hu X L, Bao W D, Song F R
General Hospital Shenyang Army, Shenyang.
Zhonghua Liu Xing Bing Xue Za Zhi. 1995 Feb;16(1):11-3.
Apolipoprotein (apo) A-I and apo B-100 were examined in 378 aging males for studying the relationship of apolipoprotein to cardiovascular diseases. The results showed that apo A-I and apo B-100 were 148 +/- 30 mg/dl, 97.3 +/- 28 mg/dl in the healthy aged subjects. Patients with CHD had the higher level of apo B-100 (P < 0.01) than the controls. Apolipoprotein A-I was decreased (P < 0.05), but apo B-100 was increased (P < 0.01) in the patients with hypertension which indicated that the change of apolipoprotein could be a factor for patients with hypertension and sensitive to CHD. There were a positive correlation between apo B-100 and apo A-I cholesterol contents (r = 0.22, P < 0.05) as well as a negative correlation between apo A-I and fibrinogen (r = -0.2, P < 0.05) contents. Our data suggested that a higher content of apo A-I and lower content of apo B-100 might serve as the protective factors for CHD.
对378名老年男性进行载脂蛋白（apo）A-I和apo B-100检测，以研究载脂蛋白与心血管疾病的关系。结果显示，健康老年受试者的apo A-I和apo B-100分别为148±30mg/dl、97.3±28mg/dl。冠心病患者的apo B-100水平高于对照组（P<0.01）。高血压患者的载脂蛋白A-I降低（P<0.05），而apo B-100升高（P<0.01），这表明载脂蛋白的变化可能是高血压患者对冠心病敏感的一个因素。apo B-100与apo A-I胆固醇含量之间呈正相关（r=0.22，P<0.05），apo A-I与纤维蛋白原含量之间呈负相关（r=-0.2，P<0.05）。我们的数据表明，较高的apo A-I含量和较低的apo B-100含量可能是冠心病的保护因素。
