Fischer H, Prast H, Philippu A
Department of Pharmacology and Toxicology, University of Innsbruck, Austria.
Eur J Pharmacol. 1995 Mar 14;275(3):R5-6. doi: 10.1016/0014-2999(95)00097-5.
The influence of nitric oxide (NO) on adenosine release was investigated by the push-pull technique in the ventral striatum of the urethane-anaesthetized rat. Superfusion with the NO donor diethylamine-NO enhanced, whereas superfusion with the NO synthase inhibitor L-NG-nitroarginine methyl ester decreased the output of adenosine. The effect of L-NG-nitroarginine methyl ester was abolished by L-arginine methyl ester. These findings indicate that, in the ventral striatum of the rat, NO modulates adenosine release.
采用推挽技术，在乌拉坦麻醉大鼠的腹侧纹状体中研究了一氧化氮（NO）对腺苷释放的影响。用NO供体二乙胺 - NO进行灌流可增强腺苷释放，而用NO合酶抑制剂L - NG - 硝基精氨酸甲酯进行灌流则会降低腺苷的释放量。L - 精氨酸甲酯可消除L - NG - 硝基精氨酸甲酯的作用。这些结果表明，在大鼠腹侧纹状体中，NO调节腺苷的释放。
