Gaudet E, Blanc J, Elghozi J L
Laboratory of Pharmacology, CNRS URA 1482, Faculty of Medicine Necker-Enfants Malades, Paris, France.
Fundam Clin Pharmacol. 1995;9(1):30-6. doi: 10.1111/j.1472-8206.1995.tb00262.x.
to examine the effect of losartan on short-term variability of blood pressure (BP) in spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats.
variability of BP was characterized during baseline condition and 20 minutes after blocking the renin-angiotensin system (RAS) with the AT1 receptor antagonist losartan (10 mg/kg, iv). A Fast Fourier Transform algorithm was used for analysis.
under baseline conditions, SHR exhibited enhanced variability of BP compared to WKY, reflected by increased standard deviation (SD) of systolic BP (SBP). On the other hand, the mid frequency (0.2-0.6 Hz, MF) and the low frequency (0.02-0.2 Hz, LF) components of SBP were exaggerated. Enhanced MF area probably reflected a hyperactivity of the sympathetic nervous system in SHR. After a single injection of losartan, the mean BP was lowered in SHR by 13 +/- 5 mmHg, mean +/- SEM, P < 0.05). In WKY, losartan solely decreased the LF component of BP. In SHR, losartan increased the MF component of BP.
losartan resulted in differential effects on BP variability in the two strains. In WKY, the RAS contributed to the genesis of LF fluctuations. In SHR, the increase in the MF component of BP after losartan probably indicated a reflex sympathetic activation triggered by vasodilation.
研究氯沙坦对自发性高血压大鼠（SHR）和Wistar Kyoto大鼠（WKY）血压（BP）短期变异性的影响。
在基线状态以及用AT1受体拮抗剂氯沙坦（10mg/kg，静脉注射）阻断肾素-血管紧张素系统（RAS）20分钟后，对BP变异性进行表征。采用快速傅里叶变换算法进行分析。
在基线条件下，与WKY相比，SHR的BP变异性增强，表现为收缩压（SBP）标准差（SD）增加。另一方面，SBP的中频（0.2 - 0.6Hz，MF）和低频（0.02 - 0.2Hz，LF）成分增大。增强的MF面积可能反映了SHR交感神经系统的过度活跃。单次注射氯沙坦后，SHR的平均BP降低了13±5mmHg，均值±标准误，P<0.05）。在WKY中，氯沙坦仅降低了BP的LF成分。在SHR中，氯沙坦增加了BP的MF成分。
氯沙坦对两种品系的BP变异性产生了不同影响。在WKY中，RAS促成了LF波动的发生。在SHR中，氯沙坦后BP的MF成分增加可能表明血管舒张引发了反射性交感神经激活。
