自发性高血压大鼠对血管紧张素III的升压反应增强：氯沙坦的作用

Enhanced pressor response to angiotensin III in spontaneously hypertensive rats: effects of losartan.

作者信息

Radhakrishnan R, Sim M K

机构信息

Department of Pharmacology, Faculty of Medicine, National University of Singapore.

出版信息

Eur J Pharmacol. 1994 Jun 23;259(1):87-90. doi: 10.1016/0014-2999(94)90163-5.

DOI:10.1016/0014-2999(94)90163-5

PMID:7957599

Abstract

The conscious spontaneously hypertensive rat (SHR), compared to its normotensive control Wistar Kyoto rat (WKY), exhibited a significantly greater pressor response to i.v. angiotensin II and angiotensin III. Losartan (10 mg/kg i.v.) lowered the basal blood pressure of the SHR but had no significant effect on that of the WKY. However, it attenuated the pressor response to both angiotensins in the SHR and WKY, the degree of attenuation being significantly greater with angiotensin III. In addition, the pressor responses induced by both angiotensin II and angiotensin III in the WKY, compared to those of the SHR, were more markedly inhibited by losartan. The results indicate a possible over-expression of angiotensin AT1 receptors in the SHR, and that both angiotensin II and angiotensin III contribute to the hypertension by acting on these receptors.

摘要

与正常血压对照的Wistar Kyoto大鼠（WKY）相比，清醒的自发性高血压大鼠（SHR）对静脉注射血管紧张素II和血管紧张素III表现出明显更强的升压反应。氯沙坦（静脉注射10mg/kg）降低了SHR的基础血压，但对WKY的基础血压没有显著影响。然而，它减弱了SHR和WKY对两种血管紧张素的升压反应，对血管紧张素III的减弱程度明显更大。此外，与SHR相比，氯沙坦对WKY中血管紧张素II和血管紧张素III诱导的升压反应的抑制作用更明显。结果表明SHR中血管紧张素AT1受体可能过度表达，并且血管紧张素II和血管紧张素III均通过作用于这些受体导致高血压。