• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

白细胞介素-4抑制肿瘤坏死因子α和β、白细胞介素-1β和-6以及干扰素-γ的表达。

Interleukin-4 inhibits the expression of tumour necrosis factors alpha and beta, interleukins-1 beta and -6 and interferon-gamma.

作者信息

Lee J D, Rhoades K, Economou J S

机构信息

Department of Surgery, Jonnson Comprehensive Cancer Center, UCLA School of Medicine 90024, USA.

出版信息

Immunol Cell Biol. 1995 Feb;73(1):57-61. doi: 10.1038/icb.1995.9.

DOI:10.1038/icb.1995.9
PMID:7768545
Abstract

T cell-derived IL-4 inhibits the expression of several inflammatory cytokine genes. In this study, IL-4 downregulated TNF-alpha and -beta, IL-1 beta IL-6 and IFN-gamma steady-state mRNA and protein production by blood leukocytes. In a detailed kinetic analysis, cytokine mRNA levels were significantly decreased in the presence of IL-4, suggesting an early and prolonged downregulatory effect. These findings support the general thesis that IL-4 is an important regulator of the inflammatory immune response.

摘要

T细胞衍生的白细胞介素-4抑制多种炎性细胞因子基因的表达。在本研究中，白细胞介素-4下调了血液白细胞中肿瘤坏死因子-α和-β、白细胞介素-1β、白细胞介素-6以及干扰素-γ的稳态信使核糖核酸（mRNA）和蛋白质生成。在一项详细的动力学分析中，在白细胞介素-4存在的情况下，细胞因子mRNA水平显著降低，提示存在早期且持久的下调效应。这些发现支持了白细胞介素-4是炎性免疫反应的重要调节因子这一总体论点。

相似文献

1
Interleukin-4 inhibits the expression of tumour necrosis factors alpha and beta, interleukins-1 beta and -6 and interferon-gamma.白细胞介素-4抑制肿瘤坏死因子α和β、白细胞介素-1β和-6以及干扰素-γ的表达。
Immunol Cell Biol. 1995 Feb;73(1):57-61. doi: 10.1038/icb.1995.9.
2
Expression of tumour necrosis factor-alpha, -beta and interferon-gamma genes within human neuroglial tumour cells and brain specimens.人神经胶质瘤细胞和脑标本中肿瘤坏死因子-α、-β及干扰素-γ基因的表达
Cytokine. 1994 Mar;6(2):171-80. doi: 10.1016/1043-4666(94)90039-6.
3
Temporal sequence and cellular origin of interleukin-2 stimulated cytokine gene expression.白细胞介素-2刺激的细胞因子基因表达的时间顺序和细胞起源
Br J Cancer. 1993 Mar;67(3):514-21. doi: 10.1038/bjc.1993.96.
4
Regulatory mechanisms for production of IFN-gamma and TNF by antitumor T cells or macrophages in the tumor-bearing state.荷瘤状态下抗肿瘤T细胞或巨噬细胞产生γ干扰素和肿瘤坏死因子的调控机制。
J Immunol. 1995 Mar 1;154(5):2281-90.
5
The cytokine microenvironment of human colon carcinoma. Lymphocyte expression of tumor necrosis factor-alpha and interleukin-4 predicts improved survival.人类结肠癌的细胞因子微环境。肿瘤坏死因子-α和白细胞介素-4的淋巴细胞表达预示着生存期延长。
Cancer. 1996 Sep 15;78(6):1168-78. doi: 10.1002/(SICI)1097-0142(19960915)78:6<1168::AID-CNCR2>3.0.CO;2-6.
6
Cytokine regulation of tumor necrosis factor-alpha and -beta (lymphotoxin)-messenger RNA expression in human peripheral blood mononuclear cells.细胞因子对人外周血单个核细胞中肿瘤坏死因子-α和-β（淋巴毒素）信使核糖核酸表达的调节
Cancer Res. 1990 Aug 15;50(16):5072-6.
7
IFN-beta inhibits the ability of T lymphocytes to induce TNF-alpha and IL-1beta production in monocytes upon direct cell-cell contact.干扰素-β抑制T淋巴细胞在直接细胞间接触时诱导单核细胞产生肿瘤坏死因子-α和白细胞介素-1β的能力。
Cytokine. 2001 Jun 7;14(5):272-82. doi: 10.1006/cyto.2001.0884.
8
Restricted T cell expression of IL-2/IFN-gamma mRNA in human inflammatory disease.
J Immunol. 1991 Aug 1;147(3):810-5.
9
Alteration in peripheral blood mononuclear cell function and serum cytokines in oral lichen planus.
J Oral Pathol Med. 1994 Jan;23(1):28-35. doi: 10.1111/j.1600-0714.1994.tb00250.x.
10
Induction of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by Pseudomonas aeruginosa and exotoxin A-induced suppression of lymphoproliferation and TNF, lymphotoxin, gamma interferon, and IL-1 production in human leukocytes.铜绿假单胞菌诱导肿瘤坏死因子（TNF）和白细胞介素-1（IL-1）以及外毒素A诱导人白细胞中淋巴细胞增殖、TNF、淋巴毒素、γ干扰素和IL-1产生的抑制。
Infect Immun. 1992 Aug;60(8):3162-8. doi: 10.1128/iai.60.8.3162-3168.1992.

引用本文的文献

1
Purification of placenta-eluted gamma globulins and their strong effect against graft-versus-host reactions in vitro and in vivo.胎盘洗脱γ球蛋白的纯化及其在体外和体内对移植物抗宿主反应的强烈作用。
Int J Hematol. 2005 Aug;82(2):162-8. doi: 10.1532/IJH97.A10506.
2
Effects of deviating the Th2-response in murine mercury-induced autoimmunity towards a Th1-response.使小鼠汞诱导的自身免疫中的Th2反应偏向Th1反应的效果。
Clin Exp Immunol. 2003 Nov;134(2):202-9. doi: 10.1046/j.1365-2249.2003.02303.x.
3
Murine metal-induced systemic autoimmunity: baseline and stimulated cytokine mRNA expression in genetically susceptible and resistant strains.
小鼠金属诱导的全身性自身免疫：基因易感和抗性品系中的基线及刺激后的细胞因子mRNA表达
Clin Exp Immunol. 2001 Oct;126(1):157-64. doi: 10.1046/j.1365-2249.2001.01636.x.
4
Induction of interleukin-4 (IL-4) by legionella pneumophila infection in BALB/c mice and regulation of tumor necrosis factor alpha, IL-6, and IL-1beta.嗜肺军团菌感染诱导BALB/c小鼠白细胞介素-4（IL-4）及肿瘤坏死因子α、IL-6和IL-1β的调节
Infect Immun. 2000 Sep;68(9):5234-40. doi: 10.1128/IAI.68.9.5234-5240.2000.
5
Fluticasone propionate-induced regulation of the balance within macrophage subpopulations.丙酸氟替卡松诱导巨噬细胞亚群间平衡的调节。
Clin Exp Immunol. 2000 Jan;119(1):4-10. doi: 10.1046/j.1365-2249.2000.01085.x.
6
Differential expression of cytokine transcripts in human epithelial ovarian carcinoma by solid tumour specimens, peritoneal exudate cells containing tumour, tumour-infiltrating lymphocyte (TIL)-derived T cell lines and established tumour cell lines.通过实体瘤标本、含肿瘤的腹腔渗出细胞、肿瘤浸润淋巴细胞（TIL）衍生的T细胞系和已建立的肿瘤细胞系，检测人上皮性卵巢癌中细胞因子转录本的差异表达。
Clin Exp Immunol. 1998 May;112(2):172-80. doi: 10.1046/j.1365-2249.1998.00576.x.
7
Interindividual variations in cytokine levels following cardiopulmonary bypass.体外循环后细胞因子水平的个体间差异。
Heart Vessels. 1997;12(3):119-27. doi: 10.1007/BF02767129.
8
A primer on cytokines: sources, receptors, effects, and inducers.细胞因子入门：来源、受体、作用及诱导剂
Clin Microbiol Rev. 1997 Oct;10(4):742-80. doi: 10.1128/CMR.10.4.742.
9
Tumor necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: evidence for production by microglia and astrocytes.致命性鼠脑型疟疾期间大脑中肿瘤坏死因子-α的表达：小胶质细胞和星形胶质细胞产生肿瘤坏死因子-α的证据
Am J Pathol. 1997 Apr;150(4):1473-86.