Kumar R
Mayo Clinic, Rochester, Minnesota 55905, USA.
J Cell Biochem. 1995 Mar;57(3):392-8. doi: 10.1002/jcb.240570304.
The central role of 1 alpha,25-dihydroxyvitamin D3 in the regulation of calcium balance is well established. By increasing the absorption of calcium in the intestine and the reabsorption of filtered calcium in the kidney tubule, the hormone maintains an appropriate calcium balance. The cellular mechanisms that underlie the increase in calcium transport in epithelial cells in response to 1 alpha,25-dihydroxyvitamin D3 are beginning to be defined. These events include an increase in the movement of calcium across the apical membrane of the cell, an increase in the movement of calcium across the cell, and an increase in the extrusion of calcium at the basolateral portion of the cell. In this Prospects article, I will discuss the nature of the various processes and proteins involved in transcellular calcium movement, and I will attempt to highlight various future areas of research.
1α,25 - 二羟维生素D3在钙平衡调节中的核心作用已得到充分确立。通过增加肠道对钙的吸收以及肾小管对滤过钙的重吸收，该激素维持着适当的钙平衡。1α,25 - 二羟维生素D3作用下上皮细胞钙转运增加所涉及的细胞机制正开始被明确。这些过程包括钙穿过细胞顶端膜的运动增加、钙穿过细胞的运动增加以及钙在细胞基底外侧部分的排出增加。在这篇展望文章中，我将讨论跨细胞钙转运中各种过程和蛋白质的性质，并试图突出未来各个研究领域。
