肾脏对钙、磷和镁稳态的调控。
Renal control of calcium, phosphate, and magnesium homeostasis.
作者信息
Blaine Judith, Chonchol Michel, Levi Moshe
机构信息
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, Colorado.
出版信息
Clin J Am Soc Nephrol. 2015 Jul 7;10(7):1257-72. doi: 10.2215/CJN.09750913. Epub 2014 Oct 6.
Abstract
Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these ions. Gastrointestinal absorption is balanced by renal excretion. When body stores of these ions decline significantly, gastrointestinal absorption, bone resorption, and renal tubular reabsorption increase to normalize their levels. Renal regulation of these ions occurs through glomerular filtration and tubular reabsorption and/or secretion and is therefore an important determinant of plasma ion concentration. Under physiologic conditions, the whole body balance of calcium, phosphate, and magnesium is maintained by fine adjustments of urinary excretion to equal the net intake. This review discusses how calcium, phosphate, and magnesium are handled by the kidneys.
摘要
钙、磷和镁是多价阳离子，对许多生物学和细胞功能都很重要。肾脏在这些离子的体内平衡中起着核心作用。胃肠道吸收与肾脏排泄保持平衡。当这些离子的身体储备显著下降时，胃肠道吸收、骨吸收和肾小管重吸收会增加，以使它们的水平恢复正常。这些离子的肾脏调节通过肾小球滤过以及肾小管重吸收和/或分泌来实现，因此是血浆离子浓度的重要决定因素。在生理条件下，通过对尿排泄进行精细调节，使其与净摄入量相等，从而维持钙、磷和镁的全身平衡。本综述讨论了肾脏如何处理钙、磷和镁。
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