Halperin R, Bracha Y, Schneider D, Maymon R, Kraicer P F, Hadas E
Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Tel-Aviv University, Israel.
Hum Reprod. 1995 Feb;10(2):324-7. doi: 10.1093/oxfordjournals.humrep.a135936.
The concentration of human decidua-associated protein (hDP) 200 was measured in 238 menstrual fluid samples obtained from normal fertile women and in 26 menstrual fluid samples obtained from infertile women who failed to conceive and menstruated following in-vitro fertilization (IVF)/embryo transfer treatment. A significant association was observed between the concentration of hDP200 and the age of the women. A maximal concentration of hDP200 was observed in women aged 28-30 years, with significantly lower concentrations in those aged 18-20 and 39-41 years. The presence of an intra-uterine device had no effect on menstrual fluid hDP200 concentrations. A significantly lower mean concentration of hDP200 (82 U/ml) was measured in menstrual fluid samples obtained from failed IVF/embryo transfer patients as compared with that in menstrual fluid samples from normal fertile women (191 U/ml). These findings support the concept that adequate endometrial function, as evaluated by menstrual fluid concentration of hDP200, is important for the success of the fertility process.
在从正常育龄妇女获取的238份月经液样本以及从体外受精（IVF）/胚胎移植治疗后未能受孕且月经来潮的不孕妇女获取的26份月经液样本中，测量了人蜕膜相关蛋白（hDP）200的浓度。观察到hDP200浓度与女性年龄之间存在显著关联。在28 - 30岁的女性中观察到hDP200的最大浓度，而在18 - 20岁和39 - 41岁的女性中浓度显著较低。宫内节育器的存在对月经液中hDP200的浓度没有影响。与正常育龄妇女月经液样本（191 U/ml）相比，从IVF/胚胎移植失败患者获取的月经液样本中hDP200的平均浓度显著较低（82 U/ml）。这些发现支持了这样一种概念，即通过月经液中hDP200的浓度评估的足够的子宫内膜功能对于生育过程的成功很重要。
