Gatti P J, Johnson T A, Phan P, Jordan I K, Coleman W, Massari V J
Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059, USA.
J Auton Nerv Syst. 1995 Mar 2;51(3):255-9. doi: 10.1016/0165-1838(94)00139-b.
Experiments utilizing surgical parasympathectomy of discrete fat pad ganglia on the surface of the heart have suggested that there are two anatomically segregated and physiologically independent parasympathetic intracardiac ganglia which are capable of selective control of sino-atrial (SA) rate and atrio-ventricular (AV) conduction. Some pharmacological data, however, are inconsistent with these conclusions. We have examined the cardiodynamic effects of discrete injections of a ganglionic blocking drug into two fat pads on the surface of the cat heart. These fat pads were shown to contain ganglion cells histologically. It was observed that vagal effects upon cardiac rate are selectively mediated by neurons located in ganglia overlying the right pulmonary veins at the junction of the right atrium and superior vena cava. On the other hand, vagal effects upon AV conduction were selectively mediated by neurons located in a fat pad at the junction of the inferior vena cava and the inferior left atrium. These pharmacological data support the concept that specific intracardiac ganglia are capable of selective control of SA rate and AV conduction.
利用对心脏表面离散脂肪垫神经节进行手术性副交感神经切除术的实验表明，存在两个在解剖学上分离且在生理上独立的心脏内副交感神经节，它们能够选择性地控制窦房（SA）率和房室（AV）传导。然而，一些药理学数据与这些结论不一致。我们研究了向猫心脏表面的两个脂肪垫中离散注射神经节阻断药物的心脏动力学效应。组织学检查显示这些脂肪垫含有神经节细胞。观察到，迷走神经对心率的影响是由位于右心房和上腔静脉交界处右肺静脉上方神经节中的神经元选择性介导的。另一方面，迷走神经对房室传导的影响是由位于下腔静脉和左下心房交界处一个脂肪垫中的神经元选择性介导的。这些药理学数据支持了特定心脏内神经节能够选择性控制窦房率和房室传导的概念。
