Yang H, Dixon M F, Zuo J, Fong F, Zhou D, Corthésy I, Blum A
Division of Gastroenterology, CHUV, Lausanne, Switzerland.
J Clin Gastroenterol. 1995 Mar;20(2):110-2. doi: 10.1097/00004836-199503000-00007.
Biopsy specimens from antral and duodenal mucosa were obtained from 64 patients with active duodenal ulcer and from 78 with nonulcer dyspepsia. Gastric metaplasia in the duodenal bulb was more frequent in patients with duodenal ulcer (82.5%) than in patients with dyspepsia and duodenitis (53.1%) or in patients with dyspepsia without duodenitis (34.5%). Helicobacter pylori infection in the duodenal bulb was found more often in patients with moderate to severe gastric metaplasia (62.3%) than in patients with mild gastric metaplasia (20%). Therefore, patients from a developing country, China, showed the same relationship between duodenitis, gastric metaplasia, duodenal colonization with H. pylori, and duodenal ulcer previously demonstrated in developed countries.
从64例活动性十二指肠溃疡患者和78例非溃疡性消化不良患者身上获取胃窦和十二指肠黏膜活检标本。十二指肠球部胃化生在十二指肠溃疡患者中更为常见（82.5%），高于消化不良合并十二指肠炎患者（53.1%）或无十二指肠炎的消化不良患者（34.5%）。中重度胃化生患者十二指肠球部幽门螺杆菌感染率（62.3%）高于轻度胃化生患者（20%）。因此，来自发展中国家中国的患者，十二指肠炎症、胃化生、十二指肠幽门螺杆菌定植与十二指肠溃疡之间的关系，与发达国家先前证明的相同。
