源自口蹄疫病毒高抗原性VP1区域140至160的序列不能引发牛T细胞针对完整病毒的应答。
Sequences derived from the highly antigenic VP1 region 140 to 160 of foot-and-mouth disease virus do not prime for a bovine T-cell response against intact virus.
作者信息
van Lierop M J, Wagenaar J P, van Noort J M, Hensen E J
机构信息
Department of Immunology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
出版信息
J Virol. 1995 Jul;69(7):4511-4. doi: 10.1128/JVI.69.7.4511-4514.1995.
Abstract
Although VP1 region 140 to 160 of foot-and-mouth disease virus (FMDV) is able to elicit neutralizing antibody in cattle, the protection against virus challenge that is conferred by peptide immunization is often poor. Here, we show that bovine T cells primed with peptides derived from this region generally show no reactivity to intact FMDV. In contrast, T-cell epitope VP4[20-34] is able to prime for a virus-specific response.
摘要
虽然口蹄疫病毒（FMDV）的VP1区域140至160能够在牛体内引发中和抗体，但肽免疫所赋予的针对病毒攻击的保护作用通常较差。在此，我们表明用源自该区域的肽引发的牛T细胞通常对完整的FMDV无反应性。相比之下，T细胞表位VP4[20 - 34]能够引发病毒特异性反应。
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