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体外再刺激 CD4+ T 细胞诱导产生的干扰素-γ与体内 FMD 疫苗诱导牛抵抗疾病和持续性感染的保护作用相关。

Interferon-γ induced by in vitro re-stimulation of CD4+ T-cells correlates with in vivo FMD vaccine induced protection of cattle against disease and persistent infection.

机构信息

Pirbright Laboratory, Institute for Animal Health, Surrey, United Kingdom.

出版信息

PLoS One. 2012;7(9):e44365. doi: 10.1371/journal.pone.0044365. Epub 2012 Sep 28.

DOI:10.1371/journal.pone.0044365
PMID:23028529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3460943/
Abstract

The immune defense against FMDV has been correlated to the antibody mediated component. However, there are occasions when some animals with high virus neutralising (VN) antibody are not protected following challenge and some with low neutralising antibody which do not succumb to disease. The importance of cell mediated immunity in clinical protection is less clear and so we investigated the source and production of interferon-gamma (IFN-γ) in re-stimulated whole blood of FMDV immunized cattle and its correlation to vaccine induced protection and FMDV persistence. We were able to show a positive correlation between IFN-γ response and vaccine induced protection as well as reduction of long term persistence of FMD virus. When combining this IFN-γ response in re-stimulated blood with virus neutralizing antibody titer in serum on the day of challenge, a better correlation of vaccine-induced protection with IFN-γ and VN antibody was predicted. Our investigations also showed that CD4+ T-cells are the major proliferating phenotype and IFN-γ producing cells.

摘要

针对口蹄疫病毒的免疫防御与抗体介导的成分有关。然而，有些动物尽管具有高病毒中和（VN）抗体，但在受到挑战后并未得到保护，而有些动物具有低中和抗体却未患疾病。细胞介导免疫在临床保护中的重要性尚不清楚，因此我们研究了口蹄疫免疫牛再刺激全血中干扰素-γ（IFN-γ）的来源和产生及其与疫苗诱导保护和 FMDV 持续存在的相关性。我们能够表明 IFN-γ反应与疫苗诱导的保护以及 FMD 病毒的长期持续存在减少之间存在正相关。当将再刺激血液中的 IFN-γ反应与挑战当天血清中的病毒中和抗体滴度相结合时，IFN-γ 和 VN 抗体与疫苗诱导的保护的相关性更好。我们的研究还表明，CD4+T 细胞是主要的增殖表型和 IFN-γ 产生细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f73/3460943/ef463d24904d/pone.0044365.g008.jpg
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