Belka C, Brach M A, Herrmann F
Abteilung für Medizinische Onkologie und Angewandte Molekularbiologie, Universitätsklinikum Rudolf Virchow, Freien Universität Berlin, Germany.
Leukemia. 1995 May;9(5):754-61.
Both structure-function analysis of hematopoietic growth factor receptors and identification of novel signal transduction molecules have provided new insights into the processes involved in signal transmission pathways engaged by hematopoietic growth factors. These investigations have pointed to the importance of post-translational modifications of pre-existing proteins, in particular tyrosine phosphorylation, in transmitting signals and thereby linking extracellular signals to the activation of nuclear effector molecules which govern gene expression. These observations not only contribute to our understanding of the pleiotropism and redundancy ascribed to hematopoietic growth factors, but also help to trace some of the molecules conferring signal specificity. It is to be expected that this rapidly evolving research field will provide us with a significant collection of new findings in the near future and that the precise understanding of the processes involved in ligand-binding and signal transmission will also stimulate the development of novel therapeutic drugs affecting these processes. This article gives a short overview on the role of tyrosine kinases and their substrates in signal transmission processes initiated by hematopoietic growth factors.
造血生长因子受体的结构-功能分析以及新型信号转导分子的鉴定，为造血生长因子所参与的信号转导途径中的相关过程提供了新的见解。这些研究表明，已有蛋白质的翻译后修饰，尤其是酪氨酸磷酸化，在信号传递中具有重要作用，从而将细胞外信号与调控基因表达的核效应分子的激活联系起来。这些观察结果不仅有助于我们理解造血生长因子的多效性和冗余性，还有助于追踪一些赋予信号特异性的分子。可以预期，这个快速发展的研究领域将在不久的将来为我们提供大量新的发现，并且对配体结合和信号传递过程的精确理解也将刺激影响这些过程的新型治疗药物的开发。本文简要概述了酪氨酸激酶及其底物在造血生长因子引发的信号传递过程中的作用。
