地中海贫血中红细胞叶酸水平低于正常的意义。
Significance of subnormal red-cell folate in thalassaemia.
作者信息
Tso S C
出版信息
J Clin Pathol. 1976 Feb;29(2):140-3. doi: 10.1136/jcp.29.2.140.
Abstract
Subnormal red-cell folate values were encountered in 20 of 63 thalassaemic subjects in a population with a low incidence of megaloblastosis. The abnormality was not associated with haematological changes of megaloblastosis and could not be explained on the basis of incomplete liberation of intra-erythrocytic folates, serum conjugase deficiency of vitamin B12 deficiency. Evidence is presented to indicate that it is unlikely to represent a state of subclinical folate deficiency. The exact cause of the abnormality is unknown.
摘要
在巨幼细胞贫血发病率较低的人群中，63名地中海贫血患者中有20人红细胞叶酸值低于正常水平。这种异常与巨幼细胞贫血的血液学变化无关，也不能用红细胞内叶酸释放不完全、血清结合酶缺乏或维生素B12缺乏来解释。有证据表明，这不太可能代表亚临床叶酸缺乏状态。这种异常的确切原因尚不清楚。
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