Yao M H, Dai Z X, Xu D Z, Yang Z C
Department of Pharmacology, School of Basic Medical Sciences, Shanghai Medical University, China.
Zhongguo Yao Li Xue Bao. 1995 Jan;16(1):36-8.
To evaluate whether there might be some difference in the action modes of nimodipine (Nim) and felodipine (Fel).
Compare the inhibitory effects of Nim and Fel with that of verapamil (Ver) as a representative of phenylalklamine on norepinephrine (NE)- and CaCl2-evoked contractions of human arteries.
In Ca(2+)-free and high K+ depolarized solution, inhibitory effects of Nim, Fel, and Ver were more potent on CaCl2-induced contractions on isolated human arteries than those on NE-induced contractions. In CaCl2-induced contraction, the pD2 values for Nim, Fel, and Ver were 7.5, 7.42, 6.35 on uterine arteries; 7.38, 7.65, 7.20 on mesenteric arteries and 7.87, 9.10, 7.32 on renal arteries, respectively. Ver inhibited 2 components of NE-evoked contraction, while Nim and Fel only inhibited extracellular Ca(2+)-dependent contractions.
The result indicates that Fel has a selective action on human renal arteries.
评估尼莫地平（Nim）和非洛地平（Fel）的作用模式是否可能存在差异。
以苯烷胺类的代表药物维拉帕米（Ver）为对照，比较尼莫地平和非洛地平对去甲肾上腺素（NE）和氯化钙诱发的人体动脉收缩的抑制作用。
在无钙和高钾去极化溶液中，尼莫地平、非洛地平和维拉帕米对氯化钙诱导的离体人体动脉收缩的抑制作用比对NE诱导的收缩作用更强。在氯化钙诱导的收缩中，尼莫地平、非洛地平和维拉帕米在子宫动脉上的pD2值分别为7.5、7.42、6.35；在肠系膜动脉上分别为7.38、7.65、7.20；在肾动脉上分别为7.87、9.10、7.32。维拉帕米抑制NE诱发收缩的两个成分，而尼莫地平和非洛地平仅抑制细胞外钙依赖性收缩。
结果表明非洛地平对人体肾动脉有选择性作用。
