阿司匹林与子痫前期的预防。澳大利亚妊娠高血压研究学会关于孕期使用低剂量阿司匹林的立场声明。

Aspirin and prevention of preeclampsia. Position statement of the use of low-dose aspirin in pregnancy by the Australasian Society for the Study of Hypertension in Pregnancy.

Brennecke S P, Brown M A, Crowther C A, Hague W M, King J, McCowan L, Morris J, North R, Pattison N, Tippett C

Department of Perinatal Medicine, Royal Women's Hospital, Melbourne, Australia.

Aust N Z J Obstet Gynaecol. 1995 Feb;35(1):38-41. doi: 10.1111/j.1479-828x.1995.tb01827.x.

Abstract

A heterogeneous group of randomized trials have been conducted using low-dose aspirin to prevent preeclampsia. The results do not support widespread use of low-dose aspirin to prevent preeclampsia. 2. On the basis of existing literature, it is reasonable to use prophylactic low-dose aspirin from early pregnancy in the following groups: (i) Women with prior fetal loss after the first trimester, with placental insufficiency (ii) Women with severe fetal growth retardation in a preceding pregnancy either due to preeclampsia or unexplained (iii) Women with severe early-onset preeclampsia in a previous pregnancy necessitating delivery at or before 32 weeks' gestation. 3. On the basis of existing literature, it is recommended that aspirin not be used in the following groups: (i) Healthy nulliparous women (ii) Women with mild chronic hypertension (iii) Women with established preeclampsia. 4. The data are sufficient to support further trials in more homogeneous select subgroups of women considered at risk of developing preeclampsia.

摘要

已经开展了一组使用低剂量阿司匹林预防子痫前期的异质性随机试验。结果不支持广泛使用低剂量阿司匹林预防子痫前期。2. 根据现有文献，在以下人群中从妊娠早期开始使用预防性低剂量阿司匹林是合理的：（i）孕中期后有过胎儿丢失且伴有胎盘功能不全的女性；（ii）既往妊娠因子痫前期或不明原因出现严重胎儿生长受限的女性；（iii）既往妊娠有严重早发型子痫前期且在妊娠32周或之前需要分娩的女性。3. 根据现有文献，建议在以下人群中不使用阿司匹林：（i）健康未生育女性；（ii）轻度慢性高血压女性；（iii）已确诊子痫前期的女性。4. 现有数据足以支持在被认为有子痫前期发病风险的更同质化特定亚组女性中开展进一步试验。