Kalogeraki A, Tzardi M, Datseris G, Kanavaros P, Karvelas C, Chalkiadakis G, Tsiftsis D, Delides G
Department of Pathology, University Hospital of Heraklion, Crete, Greece.
In Vivo. 1994 Nov-Dec;8(6):1053-6.
The proliferating cell nuclear antigen (PCNA) was studied by immunohistochemistry on FNA specimens of 20 breast (ductal) carcinomas, 20 fibroadenomas and 20 atypical fibrocystic lesions of the breast. Sixteen cases of breast carcinomas, eight fibroadenomas but no atypical fibrocystic lesions were found to display nuclear PCNA staining. A significant difference was found, between PCNA index of breast carcinomas (mean PCNA index 56%) and fibroadenomas (mean PCNA 21, 25%). This suggests that breast carcinomas display a higher proliferation index than fibroadenomas and fibrocystic disease. Furthermore, we found variations in PCNA among individual cases of breast carcinomas. This suggests that PCNA index can help in the individual approach of the proliferation rate of each tumour, a parameter of potentially importance for predicting the biological behaviour of the tumour in association with other proliferation markers.
采用免疫组织化学方法，对20例乳腺（导管）癌、20例纤维腺瘤和20例乳腺非典型纤维囊性病变的细针穿刺抽吸（FNA）标本进行增殖细胞核抗原（PCNA）研究。结果发现，16例乳腺癌、8例纤维腺瘤有核PCNA染色，但无乳腺非典型纤维囊性病变有核PCNA染色。乳腺癌的PCNA指数（平均PCNA指数56%）与纤维腺瘤（平均PCNA 21、25%）之间存在显著差异。这表明乳腺癌的增殖指数高于纤维腺瘤和纤维囊性疾病。此外，我们发现乳腺癌各病例之间PCNA存在差异。这表明PCNA指数有助于对每个肿瘤的增殖率进行个体化评估，这一参数对于结合其他增殖标志物预测肿瘤的生物学行为可能具有重要意义。
