Gallamini A, Carbone A, Lista P, Cavallero G, Reato G, Fruttero A, Novero D, Asnaghi G, di Celle P F, Foa R
Divisione di Medicina, University of Torino, Italy.
Leuk Lymphoma. 1995 Mar;17(1-2):155-61.
A case of enteropathy associated T-cell lymphoma (EATCL) in a 62-year-old female with a previous history of coeliac disease, complicated during the clinical course by massive blood and tissue eosinophilia is described. The patient's serum contained a factor capable of stimulating the in vitro growth of eosinophilic colonies (CFU-Eo), that was absent in the serum of normal donors. We suggest that such factor was Interleukin-5 (IL-5), as indicated by the presence in the monoclonal tumor T cells of IL-5 encoding mRNA, usually absent in the normal enterocytes of the jejunum.
本文描述了一例62岁患有乳糜泻病史的女性肠病相关T细胞淋巴瘤（EATCL），其临床病程中并发大量血液和组织嗜酸性粒细胞增多。患者血清中含有一种能够刺激嗜酸性粒细胞集落（CFU-Eo）体外生长的因子，而正常供体血清中不存在该因子。我们认为这种因子是白细胞介素-5（IL-5），因为在单克隆肿瘤T细胞中存在IL-5编码mRNA，而在空肠正常肠上皮细胞中通常不存在。
