Moran A P
Department of Microbiology, University College, Galway, Ireland.
FEMS Immunol Med Microbiol. 1995 Feb;10(3-4):271-80. doi: 10.1111/j.1574-695X.1995.tb00043.x.
Helicobacter pylori is an important gastroduodenal pathogen of humans. Immunological and structural studies have been performed on the phospholipids, lipopolysaccharides (LPS) and some surface proteins of H. pylori strains. H. pylori LPS has, in general, low immunological activity and this property may aid the survival of this chronic infection. Nevertheless, H. pylori LPS has been found to influence the quality of gastric mucin and to stimulate pepsinogen secretion, thereby contributing to gastric disease. A number of putative adhesins of the bacterium have been described. This multiplicity of adhesins may reflect that H. pylori adherence is a multi-step process involving different interactions, and that different adhesins may mediate adherence to various sites in gastric tissue.
幽门螺杆菌是人类重要的胃十二指肠病原体。对幽门螺杆菌菌株的磷脂、脂多糖（LPS）和一些表面蛋白进行了免疫学和结构研究。一般来说，幽门螺杆菌LPS的免疫活性较低，这一特性可能有助于这种慢性感染的存活。然而，已发现幽门螺杆菌LPS会影响胃黏液的质量并刺激胃蛋白酶原分泌，从而导致胃部疾病。已经描述了该细菌的多种假定黏附素。这种黏附素的多样性可能反映出幽门螺杆菌的黏附是一个涉及不同相互作用的多步骤过程，并且不同的黏附素可能介导对胃组织中不同部位的黏附。
