Demachi H, Matsui O, Kawamori Y, Ueda K, Takashima T
Department of Radiology, Kanazawa University School of Medicine, Ishikawa, Japan.
Cardiovasc Intervent Radiol. 1995 Mar-Apr;18(2):97-101. doi: 10.1007/BF02807230.
The role of the portal system after hepatic artery embolization (HAE) was examined.
Using a Wistar strain rat model of liver cirrhosis, the route and occurrence of portoarterial (PA) shunts before and after HAE by scanning electron microscopic (SEM) and histologic methods were evaluated. HAE was performed with iodized oil and gelatin sponge particles.
In the SEM study, PA shunts did not develop in normal rats regardless of whether they did (n = 10) or did not have HAE (n = 5). The cirrhotic rat model showed PA shunts in both HAE (n = 5) and non-HAE (n = 5) animals. PA shunts were established via the peribiliary plexus and direct arterioportal anastomosis. In the histologic study, the occurrence of PA shunts in liver cirrhosis was significantly increased by HAE (HAE = 6, non-HAE = 6, p < 0.01).
The development of PA shunts, which help perfuse liver parenchyma, may explain why HAE can be safely performed in patients with liver cirrhosis.
研究肝动脉栓塞术（HAE）后门静脉系统的作用。
采用Wistar品系肝硬化大鼠模型，通过扫描电子显微镜（SEM）和组织学方法评估HAE前后门动脉（PA）分流的途径和发生率。使用碘化油和明胶海绵颗粒进行HAE。
在SEM研究中，无论正常大鼠是否接受HAE（接受HAE的n = 10只，未接受HAE的n = 5只），均未出现PA分流。肝硬化大鼠模型在接受HAE（n = 5只）和未接受HAE（n = 5只）的动物中均显示出PA分流。PA分流通过肝门周围丛和直接动脉门静脉吻合形成。在组织学研究中，HAE显著增加了肝硬化中PA分流的发生率（接受HAE的n = 6只，未接受HAE的n = 6只，p < 0.01）。
有助于肝实质灌注的PA分流的形成，可能解释了为什么肝硬化患者能够安全地接受HAE。
