Nocentini G, Ronchetti S, Bartoli A, Testa G, D'Adamio F, Riccardi C, Migliorati G
Department of Clinical Medicine, University of Perugia, Medical School, Italy.
Eur J Immunol. 1995 May;25(5):1405-9. doi: 10.1002/eji.1830250540.
It has been previously suggested that three alternative splicings of the murine T cell receptor (TCR) zeta gene are involved in the regulation of TCR/CD3 transduction signals. We here describe a new alternative splicing of this gene (TCR iota), cloned by reverse transcriptase-polymerase chain reaction, that is encoded by exons 1-7 and 10. The protein putatively encoded by TCR iota mRNA differs in its carboxy terminus from that coded by TCR0 as a consequence of the reading frame shift of exon 10. The possible role of this new splicing in TCR modulation is briefly discussed.
先前有人提出，小鼠T细胞受体（TCR）ζ基因的三种可变剪接参与TCR/CD3转导信号的调节。我们在此描述了该基因的一种新的可变剪接（TCR ι），它是通过逆转录酶-聚合酶链反应克隆的，由外显子1-7和10编码。由于外显子10的阅读框移位，TCR ι mRNA推定编码的蛋白质在其羧基末端与TCR0编码的蛋白质不同。本文简要讨论了这种新剪接在TCR调节中的可能作用。
