Ren Pingping, Lu Luying, Cai Shasha, Chen Jianghua, Lin Weiqiang, Han Fei
Kidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Key Laboratory of Nephropathy, Zhejiang Province, Hangzhou, China.
Front Immunol. 2021 Aug 17;12:713540. doi: 10.3389/fimmu.2021.713540. eCollection 2021.
Alternative splicing (AS) is a complex coordinated transcriptional regulatory mechanism. It affects nearly 95% of all protein-coding genes and occurs in nearly all human organs. Aberrant alternative splicing can lead to various neurological diseases and cancers and is responsible for aging, infection, inflammation, immune and metabolic disorders, and so on. Though aberrant alternative splicing events and their regulatory mechanisms are widely recognized, the association between autoimmune disease and alternative splicing has not been extensively examined. Autoimmune diseases are characterized by the loss of tolerance of the immune system towards self-antigens and organ-specific or systemic inflammation and subsequent tissue damage. In the present review, we summarized the most recent reports on splicing events that occur in the immunopathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and attempted to clarify the role that splicing events play in regulating autoimmune disease progression. We also identified the changes that occur in splicing factor expression. The foregoing information might improve our understanding of autoimmune diseases and help develop new diagnostic and therapeutic tools for them.
可变剪接（AS）是一种复杂的协调转录调控机制。它影响近95%的所有蛋白质编码基因，几乎发生在所有人体器官中。异常可变剪接可导致各种神经疾病和癌症，并与衰老、感染、炎症、免疫和代谢紊乱等有关。尽管异常可变剪接事件及其调控机制已得到广泛认可，但自身免疫性疾病与可变剪接之间的关联尚未得到广泛研究。自身免疫性疾病的特征是免疫系统对自身抗原失去耐受性，出现器官特异性或全身性炎症以及随后的组织损伤。在本综述中，我们总结了关于系统性红斑狼疮（SLE）和类风湿性关节炎（RA）免疫发病机制中发生的剪接事件的最新报道，并试图阐明剪接事件在调节自身免疫性疾病进展中所起的作用。我们还确定了剪接因子表达中发生的变化。上述信息可能会增进我们对自身免疫性疾病的理解，并有助于开发针对它们的新诊断和治疗工具。
