Towler C M, Glover R G, Horne C H
Clin Chim Acta. 1978 Jul 15;87(2):289-96. doi: 10.1016/0009-8981(78)90350-9.
Evidence is presented here that variants of the human trophoblastic plasma protein, pregnancy-specific beta1-glycoprotein (PSbetaG) are detectable in plasma samples from a small percentage of subjects and may be recognised by their capacity to form indistinct immunoprecipitates and give artificially low levels when measured by radioimmunoassay. Urinary PSbetaG shows a marked degree of heterogeneity and is difficult to measure using conventional immunoprecipitation assay techniques. By radioimmunoassay, late pregnancy urinary PSbetaG concentrations have been found to be in the range 0.35 to 6.9 microgram/ml, approximately 3% of the term plasma concentrations.
本文提供的证据表明，在一小部分受试者的血浆样本中可检测到人类滋养层血浆蛋白——妊娠特异性β1-糖蛋白（PSβG）的变体，这些变体可能因其形成不清晰免疫沉淀物的能力以及通过放射免疫测定法测量时给出人为低水平值的能力而被识别。尿PSβG表现出显著的异质性，使用传统免疫沉淀测定技术难以测量。通过放射免疫测定法发现，妊娠晚期尿PSβG浓度在0.35至6.9微克/毫升范围内，约为足月血浆浓度的3%。
